DNA mutates – that’s what it does. If we go back 30,000 years there weren’t any domestic dogs, just wolves. But through a process of DNA mutation and selection humans have created hundreds of different breeds of dog, with all their distinct body sizes, shapes and behaviours. None of this would have been possible if DNA didn’t mutate. Continue reading
The Canine Genetics Centre (CGC) is enormously proud of its publication record. Since the year 2000 the CGC team members have published well over 100 peer-reviewed papers, the majority in open-access scientific journals with global readership. However we are often asked “why publish our results and give away our secrets”, so this week we are going to answer that very question. Continue reading
April 25th is National DNA Day and commemorates the day in 1953 when James Watson, Francis Crick, Rosalind Franklin, Maurice Wilkins and co-workers published the structure of DNA in the journal Nature. Continue reading
The CGC’s DNA sample collection is unique. Developed over the last quarter of a century, and comprising DNA samples from over 42,000 different dogs, it has been used to identify over 30 different mutations that cause inherited diseases in well over 40 different breeds. But beyond its historic use, the CGC’s sample collection is the foundation for all the CGC’s current research projects, including our investigations of inherited eye diseases, idiopathic epilepsy and intervertebral disc disease. Continue reading
A question that members of the Canine Genetics Centre (CGC) are sometimes asked is how we decide which diseases to investigate. The answer depends on a number of factors, the most important of which are DNA Samples, clinical expertise, breed community engagement, genetics expertise and funding. Continue reading
On 1 November, Dr. Cathryn Mellersh, principal investigator at the Canine Genetics Centre, and Karen Wild, clinical animal behaviourist, dog trainer, and author, participated in a series of radio interviews across the UK. The aim was to engage listeners in the science behind Wisdom Panel’s latest DNA testing innovation, which explores the genetic foundations of dog behaviour. Wisdom Panel has launched a pioneering behaviour insights feature within its portfolio of dog DNA tests, making it the only dog DNA service to characterise the genetic links influencing dogs’ individual tendencies – from splooting to anxiety and much more. Continue reading
A couple of weeks ago Bryan gave you an overview on our sample database, but how do we get from those samples to creating a DNA test for breeders to use? Well, it’s a long process and this week we are going to explain how we use whole-genome sequencing (WGS) to find plausible candidate variants which are then taken into our lab for validation. Continue reading
With the recent launch of the Paradoxical pseudomyotonia (PP) test in the Cocker Spaniel, we have seen an increase in breeders asking whether it is OK to breed with carrier dogs or not. This is not a simple yes/no question and we need to look at a lot more information than just the single CARRIER result that you might have received. Please read more from our experts to help you better understand this area and what is best for your personal breeding program. Continue reading
