A Focus on Eyes

Last month we told you about an eye disease variant we recently identified in the English Shepherd Breed. Today we wanted to give you a bit more information on the research we do into inherited eye diseases (IED), all of which is now carried out under the CRIEDD (Consortium to Research Inherited Eye Diseases in Dogs ) project. Continue reading

Canine Genetics Centre researchers collaborate with specialist veterinary neurologist to identify genetic cause of dog’s illness.

Most of the researchers who work in the Canine Genetics Centre (CGC) are geneticists and we regularly collaborate with colleagues from the veterinary profession to ensure that we fully understand the diseases that we investigate, and that the dogs we include in our investigations have been robustly diagnosed. Continue reading

Launch of DNA test for progressive retinal atrophy in the English Shepherd dog

The Canine Genetics Centre (CGC) is excited to announce the launch of a new DNA test, for progressive retinal atrophy (PRA) in the English Shepherd Dog, a breed that has shared ancestry with the Border Collie, the Rough Collie and the Australian Shepherd. Continue reading

Introducing Bruno Lopes – PhD student based in the Canine Genetics Centre

We would like to introduce you to Bruno Lopes. Bruno is a veterinary neurologist, from Southfields Veterinary Specialists, who has recently started studying for a PhD on a part-time basis at Cambridge University Vet School. Bruno, who will be based within the Canine Genetics Centre, will be investigating the genetics of intervertebral disc diseases in several breeds of dog, the aim being to improve our understanding of the genetics of this complex, debilitating disease that affects some of the UK’s most popular breeds. Continue reading

Update on Primary Hyperparathyroidism in Keeshonds

We are still trying to identify the genetic change that causes Primary Hyperparathyroidism (PHPT) in the Keeshond. It is proving to be much more challenging than initially anticipated, which may explain, at least in part, why the original research was never completed and published.

As part of the original Give a Dog a Genome project, we used short-read based Whole Genome Sequencing (WGS) to sequence a PHPT case and an epilepsy case (as a PHPT control). We have sequenced a further case and a progressive retinal atrophy (PRA) case as a control, giving us two cases and two controls. These data have enabled us to independently identify the chromosome that harbours the causative genetic mutation for PHPT, however we have been unable to precise variant.

We have recently been awarded a small grant from CamVet to undertake long-read sequencing of the candidate region in an attempt to identify additional variants. Preliminary data suggests that the region of interest is highly structurally complex and very difficult to interrogate, but sequencing and data analysis is ongoing.

Update from Crufts 2024

The Canine Genetics and Canine Genetics Testing teams shared a stand for a busy four days at Crufts 2024.

We would like to thank everyone who came and visited us to ask about genetic testing, to make donations to our appeal and to wish us well. It was fantastic to meet in person so many people who have donated to help support the CGC, from the UK and form further afield – we think California was the furthest that anyone had travelled! Continue reading

Epilepsy programme update

Alongside our current genetic investigations of idiopathic epilepsy in the Border Collie and Italian Spinone, we are embarking on an exciting new study starting this year to investigate the genetics of epilepsy in five new breeds – the Beagle, English Springer Spaniel, Giant Schnauzer, Hungarian Vizsla and Irish Setter. Continue reading

Funding Update

The canine genetics team would like to express their profound gratitude for all the supportive messages that we have received since Cathryn’s presentation last week. It has been very heartwarming to hear how much our work is appreciated, all around the world, and what a difference we have made to so many breeds. Continue reading