Mutation responsible for multiocular defect in the Old English Sheepdog identified

In 2017, as part of the Give a Dog a Genome project, we sequenced the genome of an Old English Sheepdog (OES) that had been diagnosed with hereditary cataracts under the BVA/KC/ISDS Eye Scheme. This was the start of a project that turned out to be a lot more complex than we initially thought it would be, and that was disrupted by both covid and our move from the Animal Health Trust to the University of Cambridge, but that we finally concluded at the end of last year. Continue reading