Investigating the genetics of disc calcification in Dachshunds

We have introduced Bruno Lopes to our supporters before – Bruno is a veterinary neurologist, from Southfields Veterinary Specialists, who has recently started studying for a PhD on a part-time basis at Cambridge Vet School. For his PhD, Bruno will be investigating the genetics of Intervertebral disc disease (IVDD), the most common cause of spinal injury in dogs. IVDD can affect all breeds but chondrodystrophic (short-legged) breeds are at highest risk and Dachshunds are more likely to be affected by IVDD than other breeds. Continue reading

Paper detailing PRA modifier frequencies published

The Canine Genetics Centre has had an important study published, in collaboration with Wisdom Panel, on the genetics of progressive retinal atrophy in dogs. The paper describes the frequency of two genetics variants, called RPGRIP1ins44 and MAP9del, in 132 different breeds of dog. Both the variants were originally identified in Miniature Longhaired Dachshunds, and both are known to modify the development and progression of PRA. Continue reading