In 2017, as part of the Give a Dog a Genome project, we sequenced the genome of an Old English Sheepdog (OES) that had been diagnosed with hereditary cataracts under the BVA/KC/ISDS Eye Scheme. This was the start of a project that turned out to be a lot more complex than we initially thought it would be, and that was disrupted by both covid and our move from the Animal Health Trust to the University of Cambridge, but that we finally concluded at the end of last year. Continue reading
Tag: Multiocular defect (MOD)
Multiocular defect in Old English Sheepdogs
In recent years multiple dogs of the Old English Sheepdog (OES) breed have been diagnosed with an ocular (eye) disease that can affect multiple parts of the eye and is therefore known as multiocular defect (MOD). Most affected dogs suffer from cataracts, but additional abnormalities can include any of the following:
- microphakia (small lens),
- lens coloboma (a hole in the lens),
- macrophthalmos (enlarged globe),
- retinal detachment,
- vitreopathy and
- retinal degeneration
