Our currently funded CGC Idiopathic Epilepsy (IE) project has now entered its final stage as we move towards the end of this year. As always, a huge thank you to everyone who has sent us swabs or completed our epilepsy questionnaire, especially those of you who have organised big batches of cheek swab DNA collection kits! Continue reading
Since our last update, the CGC Idiopathic Epilepsy (IE) project has had a great response to our call for samples. A huge thank you to everyone who has sent us swabs or completed our epilepsy questionnaire, especially those of you who have been organising big batches of cheek swab DNA collection kits! Continue reading
On Friday March 21st, 2025, the Canine Genetics Centre team welcomed thirty enthusiastic delegates to the University of Cambridge’s West Hub building for their second Research Day.
Over the course of the day the delegates were treated to talks on the CGC’s inherited eye disease, idiopathic epilepsy and intervertebral disc disease research and how the CGC investigates new and emerging diseases. The talks were well received, with everyone asking lots of questions and really engaging with the researchers about the work that the CGC does. Continue reading
In this week’s feature, we talk to Jim Johnson, Idiopathic Epilepsy Study Coordinator at the Canine Genetics Centre (CGC). Jim joined the team over three years ago, not long after its move to the University of Cambridge. Working closely with Dr Sally Ricketts and Dr Chris Jenkins in the idiopathic epilepsy team, Jim liaises with dog owners, breeders, and vets to encourage participation in epilepsy research. We spoke to Jim about his work and how his Border Collie, Nell, ensures he never sits still for long. Continue reading
We have recently published our preliminary genetic investigation of idiopathic epilepsy in the Italian Spinone breed in the peer-reviewed, open access journal, PLOS One.
Jenkins CA, De Risio L, Lophatananon A, Lewis TW, Foster D, Johnson J, Lohi H, Mellersh CS, Ricketts SL. Genome-wide association study of idiopathic epilepsy in the Italian Spinone dog breed. PLoS One. 2025 Mar 5;20(3):e0315546. doi: 10.1371/journal.pone.0315546.
The CGC’s DNA sample collection is unique. Developed over the last quarter of a century, and comprising DNA samples from over 42,000 different dogs, it has been used to identify over 30 different mutations that cause inherited diseases in well over 40 different breeds. But beyond its historic use, the CGC’s sample collection is the foundation for all the CGC’s current research projects, including our investigations of inherited eye diseases, idiopathic epilepsy and intervertebral disc disease. Continue reading
The CGC Idiopathic Epilepsy (IE) project is progressing well. We are still collecting samples from affected dogs of any age and unaffected dogs aged 8 or older across the five breeds: Beagles, English Springer Spaniels, Giant Schnauzers, Hungarian Vizslas, and Irish Setters. The IE team is now collating and extracting DNA from around 250 new samples submitted since the project’s launch. The graph shows samples received and kit requests still awaiting return—the target is 200 per breed. Continue reading
This is the second in our series of ‘Spotlight’ articles where we focus on a breed that the Canine Genetics Centre (CGC) has worked closely with over many years to investigate the inheritance of disorders that represent a challenge to their health. This time we describe our work with the Italian Spinone breed community to understand the underlying genetics of two devastating diseases, one of which has now had a DNA test available for over 15 years that has been successfully used to reduce the number of affected dogs born with this debilitating disease. Continue reading
The CGC’s idiopathic epilepsy research project has taken on a real Vizsla vibe this week, as dozens of Vizsla owners from around the world have reached out to support our work. Continue reading
On November 14th 2024 Dr. Cathryn Mellersh, Head of the Canine Genetics Centre, gave an online presentation to our supporters and stakeholders. Cathryn started her presentation by summarising the areas of research that the CGC has been involved with over the last twelve months, including details of the impressive list of peer-reviewed publications that the team has produced. Continue reading
