High five to our five epilepsy breeds – but we’re not done yet!

The CGC Idiopathic Epilepsy (IE) project is progressing well. We are still collecting samples from affected dogs of any age and unaffected dogs aged 8 or older across the five breeds: Beagles, English Springer Spaniels, Giant Schnauzers, Hungarian Vizslas, and Irish Setters. The IE team is now collating and extracting DNA from around 250 new samples submitted since the project’s launch. The graph shows samples received and kit requests still awaiting return—the target is 200 per breed. Continue reading

Multiocular Defect in the Cocker Spaniel – The Next Challenge

The Cocker Spaniel is one of the most popular dog breeds in the UK and so it is unsurprising that a number of inherited diseases have been reported over the years in this breed including Progressive Retinal Atrophy (PRA), Retinal Dysplasia (RD) and Retinopathy with Vitamin E Deficiency (RVED). A DNA test for PRA (prcd) has been available for a long time and so this disease is now, fortunately, very rare in this breed. Very recently, the Canine Genetics Centre has also solved the cause of RVED in this breed and so, with the use of DNA testing, this disease should be easy to eradicate in a few generations. Continue reading

Where are we now? – CGC updates via an online presentation

On November 14th 2024 Dr. Cathryn Mellersh, Head of the Canine Genetics Centre, gave an online presentation to our supporters and stakeholders. Cathryn started her presentation by summarising the areas of research that the CGC has been involved with over the last twelve months, including details of the impressive list of peer-reviewed publications that the team has produced. Continue reading

Collaboration across the world to identify genetic cause for wobbly puppies

Our team at the Canine Genetics Centre are often contacted to collaborate with veterinary professionals and owners from around the world when it comes to challenging canine genetic problems. We recently received a communication from a Welsh Springer Spaniel breeder from Australia asking for our expertise regarding two wobbly puppies out of one litter of nine. Continue reading

First genetic investigation of a movement disorder in Norwich Terriers published

Norwich Terrier GWAS PxDWe have recently published our preliminary genetic investigation of paroxysmal dyskinesia (PxD), a movement disorder, that is prevalent in the numerically small Norwich Terrier breed and for which no cause has been established to date in this breed. Our paper has been published in the peer-reviewed, open access journal, Animal Genetics.

Jenkins CA, De Risio L, Dietschi E, Leeb T, Rytz U, Schawalder P, Schoenebeck JJ, Mellersh CS, Ricketts SL. A preliminary genome-wide association study of paroxysmal dyskinesia in the Norwich TerrierAnim Genet. 2024 Oct 12. doi: 10.1111/age.13479

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CGC and veterinary hospital team up for innovative investigations

The two main specialist areas of focus for our work in the Canine Genetics Centre (CGC) are ophthalmology and neurology. For this week’s newsletter, Dr Sally Ricketts, Senior Research Associate, tells us about how the CGC joins forces with the Queen’s Veterinary School Hospital (QVSH) to enhance our research into these conditions. Continue reading

Cocker Crazy at the KC International Agility Festival!

Last weekend we attended one of the largest Dog Agility shows in the UK, the Kennel Club International Agility Festival (KCIAF), where we met up with over 100 Cocker Spaniels. We were collecting data for research into Intervertebral Disc Disease (IVDD) as part of Bruno’s PhD. Continue reading

Mutation responsible for progressive retinal atrophy in the English Shepherd published

Back in March, CAGT launched a DNA test for progressive retinal atrophy (PRA) in the English Shepherd Dog breed (PRA6). Since then we have been working on a manuscript detailing our research and we are very pleased to announce that it was published last Sunday in Genes.

Stanbury K, Schofield EC, McLaughlin B, Forman OP, Mellersh CS. Exonic Short Interspersed Nuclear Element Insertion in FAM161A Is Associated with Autosomal Recessive Progressive Retinal Atrophy in the English ShepherdGenes. 2024; 15(7):952. doi: 10.3390/genes15070952

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Investigating the genetics of disc calcification in Dachshunds

We have introduced Bruno Lopes to our supporters before – Bruno is a veterinary neurologist, from Southfields Veterinary Specialists, who has recently started studying for a PhD on a part-time basis at Cambridge Vet School. For his PhD, Bruno will be investigating the genetics of Intervertebral disc disease (IVDD), the most common cause of spinal injury in dogs. IVDD can affect all breeds but chondrodystrophic (short-legged) breeds are at highest risk and Dachshunds are more likely to be affected by IVDD than other breeds. Continue reading