A question that members of the Canine Genetics Centre (CGC) are sometimes asked is how we decide which diseases to investigate. The answer depends on a number of factors, the most important of which are DNA Samples, clinical expertise, breed community engagement, genetics expertise and funding. Continue reading
News
Watching for inherited eye disease in every dog breed
This week, we turn our focus to Dr Katherine Stanbury, who manages our inherited eye disease programme, CRIEDD (Consortium to Research Inherited Eye Disease in Dogs). The CRIEDD project was established in 2019 with funding from Dogs Trust, and Katherine joined the group that same year. “It was serendipitous that I took on this role,” Katherine said. “I re-homed my dog Wyatt from Dogs Trust a few years before.” Continue reading
Spotlight on the Staffordshire Bull Terrier
The Canine Genetics Centre has worked closely with many breeds over the years, to investigate inherited disorders that represent a challenge to their health. In the first of a series of ‘Spotlight’ articles we would like to share the story of how we worked with the Staffordshire Bull Terrier community to understand the underlying genetics of two serious and debilitating diseases and develop DNA tests for them both, thus providing the tools with which to eradicate both these conditions from this much-loved breed. Continue reading
Tails of teamwork: Vizsla community rallies to support epilepsy research
The CGC’s idiopathic epilepsy research project has taken on a real Vizsla vibe this week, as dozens of Vizsla owners from around the world have reached out to support our work. Continue reading
Where are we now? – CGC updates via an online presentation
On November 14th 2024 Dr. Cathryn Mellersh, Head of the Canine Genetics Centre, gave an online presentation to our supporters and stakeholders. Cathryn started her presentation by summarising the areas of research that the CGC has been involved with over the last twelve months, including details of the impressive list of peer-reviewed publications that the team has produced. Continue reading
Tuning in to canine conversations: CGC and Wisdom Panel hit the airwaves
On 1 November, Dr. Cathryn Mellersh, principal investigator at the Canine Genetics Centre, and Karen Wild, clinical animal behaviourist, dog trainer, and author, participated in a series of radio interviews across the UK. The aim was to engage listeners in the science behind Wisdom Panel’s latest DNA testing innovation, which explores the genetic foundations of dog behaviour. Wisdom Panel has launched a pioneering behaviour insights feature within its portfolio of dog DNA tests, making it the only dog DNA service to characterise the genetic links influencing dogs’ individual tendencies – from splooting to anxiety and much more. Continue reading
Collaboration across the world to identify genetic cause for wobbly puppies
Our team at the Canine Genetics Centre are often contacted to collaborate with veterinary professionals and owners from around the world when it comes to challenging canine genetic problems. We recently received a communication from a Welsh Springer Spaniel breeder from Australia asking for our expertise regarding two wobbly puppies out of one litter of nine. Continue reading
First genetic investigation of a movement disorder in Norwich Terriers published
We have recently published our preliminary genetic investigation of paroxysmal dyskinesia (PxD), a movement disorder, that is prevalent in the numerically small Norwich Terrier breed and for which no cause has been established to date in this breed. Our paper has been published in the peer-reviewed, open access journal, Animal Genetics.
Jenkins CA, De Risio L, Dietschi E, Leeb T, Rytz U, Schawalder P, Schoenebeck JJ, Mellersh CS, Ricketts SL. A preliminary genome-wide association study of paroxysmal dyskinesia in the Norwich Terrier. Anim Genet. 2024 Oct 12. doi: 10.1111/age.13479
BIG data gives us BIG results but also BIG headaches!
A couple of weeks ago Bryan gave you an overview on our sample database, but how do we get from those samples to creating a DNA test for breeders to use? Well, it’s a long process and this week we are going to explain how we use whole-genome sequencing (WGS) to find plausible candidate variants which are then taken into our lab for validation. Continue reading
More bang for your bark – PBGVs will double your donation
The Petit Basset Griffon Vendéen used to suffer from a painful and blinding eye disease called Primary Open Angle Glaucoma. But thanks to research by the Canine Genetics Centre, in collaboration with veterinary ophthalmologists and the worldwide PBGV owning and breeding community, the causal mutation was identified and published in 2015. Continue reading
